Therapeutic potential of transcranial magnetic stimulation (TMS) in substance use disorders

Prof. Antonello Bonci

Global Institutes on Addiction, Miami, FL

DATE: 1st September 2019
TIME: 09:00 – 10:00 am
LOCATION: Centro Linguistico Ateneo, Padova

More than 20 million people worldwide struggle with cocaine addiction. However, no neurobiological treatment for cocaine has been approved yet. Furthermore, the majority of patients wonder whether there is any viable cure for this chronic, relapsing condition. None of the conventional approaches – often long, arduous, painful, not devoid of relapses – have proven effective in more than a small percentage of patients. After years of research, our team is proud to present the results that have transformed lives of patients and the approach to treating cocaine addiction, and the clinical courses of addiction. This innovative treatment is based on a non-invasive brain stimulation technology called repetitive transcranial magnetic stimulation (rTMS), virtually free of any significant side effects. Developed and perfected in our Clinics since the beginning of 2014, with more than 1,000 patients treated thus far, this painless approach has proved to be effective in improving decision-making, and reducing craving for cocaine. In fact, patients undergoing our treatment report a greater control of their actions and a reduction of both craving and relapse. During my lecture, I’ll provide a full overview of the rationale and use of rTMS application as interventional tool for treating Cocaine use disorders and other forms of addictions.



Current Position:    President and Co-Founder, Global Institutes on Addiction, Miami, FL

Affiliations:             Adjunct Professor of Neuroscience, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine

Adjunct Professor of Psychiatry, Department of Psychiatry and Behavioral Sciences,

Johns Hopkins University School of Medicine

Adjunct Professor of Psychiatry, Department of Psychiatry

University of Maryland, School of Medicine

Adjunct Professor, Department of Neuroscience, Georgetown University Medical Center, School of Medicine


1985-1991                  Catholic University of Sacred Heart, School of Medicine, Rome, Italy, M.D.

Summa cum laude

1991-1995                  Resident, School of Neurology, University of Rome ‘Tor Vergata’, Rome, Italy

Summa cum laude

1994-1996                  Postdoctoral Fellowship, Vollum Institute for Advanced Biomedical Research,

Portland, OR, Sponsor: Dr. J.T. Williams


1995-Present              Licensed M.D. (1991) and neurologist (1995), Italy. License # 01099.


2010-2019                 Scientific Director, National Institute on Drug Abuse, National Institutes of Health

2010-2019                 Chief, synaptic plasticity section, NIDA, NIH

2009-2010                        Associate Director, Extramural Affairs, Ernest Gallo Clinic and Research Center

2007-2010                             Professor in Residence, Dept. of Neurology, UCSF

2006-2010                             Howard J. Weinberger Endowed Chair in Addiction Research at UCSF

2004-2007                             Associate Professor in Residence, Dept. of Neurology, UCSF

1999-2010                             Principal Investigator, Ernest Gallo Clinic and Research Center

1999-2004                             Assistant Professor in Residence, Dept. of Neurology, UCSF

1999-1999                             Visiting Assistant Professor, Dept. of Neurology, UCSF

1998-1999                   Visiting Assistant Professor, Dept. of Psychiatry, University of California, San Francisco (UCSF), Sponsor:  Prof. Robert C. Malenka

1996-1998                              Medical Executive, first level, IRCCS Hospital S. Lucia, Dept. of Neurorehabilitation and Dept. of Pharmacology, Rome, Italy


Apr 2019        Member, American Academy of Physicians

Dec 2018        Chair, Section IG03, National Academy of Medicine

Feb 2017       Distinguished Scientist Award, University of North Carolina-Chapel Hill

Jan 2017                     Member, The Dana Alliance for Brain Initiatives (DABI)

Oct 2016       Member, National Academy of Medicine

Jun 2015      Federation of European Neuroscience Societies (FENS) European Journal of Neuroscience (ENJ) Research Award

2015-2018      Member, ACNP Executive Committee Council

Dec 2014        Fellow, American College of Neuropsychopharmacology

Feb 2014        Officer, Order of the Star of Italy

Aug 2013        Chair, Gordon Research Conference on Catecholamines, West Dover, VT

May 2013     Outstanding Physician Scientist Award, GeneExpression Systems Inc., and Appasani Research Conferences and Educational Institute

Dec 2009      President, Scientific Committee, Presidency of the Council of Ministers, Department for

-2010      Anti-Drug Policies, Italy

Dec 2009        D. Efron Award, American College of Neuropsychopharmacology

Oct 2004        Jacob P. Waletzky Memorial Award, Society for Neuroscience

Mar 1999       Fondazione Cassa di Risparmio di Rimini Award (Italy)


Extramural Activities

2019               Member, the Under-represented Minority Task Force, ACNP

2018               Chair, Section IG03, National Academy of Medicine

2017-2019      Member, Jacob P. Waletzky Award Selection Committee, Society for Neuroscience

2017                Member, The Dana Alliance for Brain Initiatives (DABI)

2017               Member, National Academy of Medicine (NAM)

2017               Member, Neurobiology of Addiction Research Center (NARC) Advisory Review Board, MUSC

2016-2017    Member, Personal Support Network Clinic (PerSoN) Advisory Board

2015               Member, European Project Advisory Board, University of Florence

2015-2016      Member, Discovery Engine Advisory Board

2015-2016      Member, Consortium Advisory Board, Institute for Translational Neuroscience, UCSF

2014-2016      Member, International Advisory Board, Dopamine 2016

2012-2016      Member, UCLA, CSORDA Advisory Board

2012-2014      Member, Institute for Molecular Neuroscience Advisory Council, UCSF

2006                Ad Hocmember, Scientific Advisory Board for the Extramural Program,

National Institute on Alcohol Abuse and Alcoholism

2005-2008      Member, Research Society on Alcoholism Priorities Committee

Clinical and Related Activities

Licensed neurologist, Italy. Current active practice.

Coordinator of clinical studies on substance abuse, in collaboration with ASLL 20, Verona, Italy. (Terminated as of August 2010)

Professional Societies and Related Services

1995-Present              American Society for Neuroscience

1999-Present              Research Society on Alcoholism

2005-Present              American Neurological Association

2007-Present              American College of Neuropsychopharmacology (ACNP)

2012-2014                  ACNP, Membership Committee

2013-present              ACNP, Program Planning Committee

2013-present              Italian Institute of Technology, Advisory Board Member

Service to Professional Publications

Direct Submission Editor, PNAS

Section Editor, European Journal of Neuroscience

Editorial Board Member, Biological Psychiatry

Associate Editor, Frontiers in Addictive Disorders

Editorial Board Member, Open Neuroscience

Editorial Board Member, Biological Psychiatry,Cognitive Neuroscience and Neuroimaging

Co-Editor,Frontiers Journal, Brain Activity Mapping

Associate Editor, The Journal of Neuroscience (term ended)

Associate Editor, Alcoholism:Clinical and Experimental Research (term ended)

Ad HocReviewer:





Nature Neuroscience

Nature Medicine

Nature Communications

Proceedings of the National Academy of Science USA

Journal of Neuroscience

Journal of Neurophysiology

European Journal of Neuroscience

Journal of Pharmacology and Experimental Therapeutics


Biological Psychiatry





Annals of Neurology

The Lancet

Neurophysiologie Clinique

 Grant Reviews

1999                UCSF, Center for the Neurobiology of Drug Addiction, intramural grant reviewer

2000                UCSF, Center for the Neurobiology of Drug Addiction, intramural grant reviewer

2002                NIH/NIDA CEBRA program grant reviewer

2002               Loyola University, intramural grant reviewer

2002               University of Texas at Austin, intramural grant reviewer

2003               UC Discovery program, grant reviewer

2003               National Science Foundation, grant reviewer

2003               NIH, grant reviewer

2004                NIH RFA study section, grant reviewer

2005               NIH CEBRA program, grant reviewer

2005               NIH special study section, grant reviewer

2005-2010     NIH NMB, study section, regular member, grant reviewer

2013               NIH NMB study section, ad-hocgrant reviewer

2014-2016      Biomedicine & F.I.R.S.T Program Israel Science, grant reviewer

2014-2016      The French National Research Agency (ANR), grant reviewer

2015              German Research Foundation (DFG), ad-hocgrant reviewer

2016               National Science Centre Poland, grant reviewer

2016               Swiss National Science Foundation, grant reviewer

2016               Helis Henry Medical Research Foundation, grant reviewer

2016               US-Israel Binational Science Foundation, grant reviewer

2017               European Research Council, grant reviewer

2017               Swiss National Science Foundation, grant reviewer

2017               Fund for Scientific Research-FNRS (F.R.S.-FNRS), grant reviewer

2018               European Research Council (ERC), grant reviewer

2018              Alcohol and Substance Abuse Disorders Research Program, grant reviewer

2018               US-Israel Binational Science Foundation, grant reviewer

2018               Boehringer Ingelheim Fonds PhD fellowship, reviewer

2018               Swiss National Science Foundation, grant reviewer

2018               Fund for Scientific Research-FNRS (F.R.S.-FNRS), grant reviewer

2018               Department of Veteran Affairs Office of Research Development, grant reviewer

2018               MRC Peer Review, grant reviewer

2018               Karolinska Institutet to the Knut and Alice Wallenberg Foundation, grant reviewer

Official Collaborations

Paul Worley, John Hopkins School of Medicine

Consultant, Robert Malenka, Stanford University

Consultant, Eric Nestler, Mount Sinai School of Medicine

Consultant, Alfredo Fontanini, Stony Brook University

Consultant, Randy Blakely, Vanderbilt University

Kevin Beier, Stanford University

Consultant, Tommi Raij, Northwestern University

Barry Everitt, University of Cambridge

Karl Deisseroth, Stanford University

Luigi Gallimberti, IRCCS San Camillo, Venice, Italy

Special Lectures

Nov 2019       William R. and Irene D. Miller Lecture, Distinguished Lecture – Cold Spring Harbor

June 2019     Keynote Speaker, OptoDBS 2019 (Invited Speaker) University of Geneva / Synaptic Disease Association. Geneva, Switzerland.

June 2019      Keynote Speaker, 13th International Congress of Addictology. Paris, France

May 2019      Keynote Speaker, Perinatal Origins of Neuropsychiatric Disorders: from Molecular Mechanisms to Therapeutic Perspectives, Palermo, Italy

Apr 2019     Presidential lecture, Society on NeuroImmune Pharmacology (SNIP) 25th Scientific Conference, Oregon

Mar 2019      Keynote Speaker, Medicinal Chemistry and Molecular Pharmacology (MCMP) graduate student body seminar at Purdue University. West Lafayette, IN

Feb 2019       Keynote Speaker, Department of Physiology and Pharmacology Seminar Series, Wake Forest School of Medicine. Winston-Salem, NC

Dec 2018      Keynote Speaker, American College of Neuropsychopharmacology, Hollywood, FL

Nov 2018      Keynote Speaker, Society for Neuroscience (Member), San Diego, CA

Nov 2018      Keynote Speaker, Shanghai Institute for Advanced Immunochemical Studies (SIAIS) Bioforum on Shanghai Tech University, Shanghai, China

Oct 2018       Keynote Speaker, Frontiers in Addiction Research and Pregnancy at the Morehouse School of Medicine, Georgia, ATL

Oct 2018      Keynote Speaker, National Academy of Medicine Member, Washington DC

Oct 2018      Keynote Speaker, American Society of Addiction Medicine (ASAM) State of the Art Course in Addiction Medicine, Washington DC

Oct 2018         Plenary Speaker, University of Minnesota, Minneapolis, MN

June 2018     Keynote Speaker, UC Irvine Center for Addictive Neuroscience (ICAN), Irvine, CA

Mar 2018      Keynote Speaker, Distinguished Lecture Series, University of California, Los Angeles (UCLA), Los Angeles, CA

Sept 2017     Keynote Speaker, 2ndAnnual 2017 Brookstone Conference, Northwestern University, Chicago, IL

May 2017      Plenary Speaker, The International Taiwanese Congress of Neurology, Taipei, Taiwan

May 2017      Plenary Speaker, Academia Sinica, Taipei, Taiwan

May 2017      Plenary Speaker, National Taiwan Medical School

May 2017      Plenary Speaker, Johns Hopkins Neurology Research Retreat

Oct 2016        Plenary Speaker, Universita di Camerino, Camerino (MC) Italy

Sep 2016       Plenary Speaker, First World Congress on Alcohol and Alcoholism (ISBRA& ESBRA meeting), Berlin, Germany

Jul 2016          Federation of European Neuroscience Societies (FENS) European Journal of Neuroscience (ENJ) Research Award Lecture

May 2016     Keynote Speaker, Louisiana State University Health Sciences Center, Alcohol & Drug Abuse Center

Feb 2016        Keynote Speaker, The 11thConference of Italian Researchers in the World, Houston TX

Dec 2015        Keynote speaker, University of Maryland Festival of Science, Baltimore, MD

Oct 2015        Keynote Speaker, Brown University, Providence, RI        

Oct 2015      Plenary Speaker, IPA International Psychogeriatric Association International Congress, Berlin, Germany

Mar 2015       Plenary Lecture, Study in Multidisciplinary Pain Research (SIMPAR) 7thMeeting, Italy

Dec 2014        Keynote Speaker, Baltimore Chapter Society for Neuroscience, Baltimore, MD

Sep 2014        Plenary Speaker, NIH Research Festival, Bethesda, MD

Jul 2014                     Keynote Speaker, International Narcotics Research Conference, Montreal, Canada

Jun 2014       Plenary Speaker, 8thALBATROS Congress, International Congress of Addictology, Paris, France

May 2014      Plenary Speaker, World Society of Intravenous Anesthesia, Bulgaria

May 2014      Plenary Speaker, 16th Annual IBANGs Meeting, Chicago, IL

Mar 2014       Plenary Speaker, Study in Multidisciplinary Pain Research (SIMPAR), Rome, Italy

Oct 2013        Flexner Lecture, University of Pennsylvania, Philadelphia, PA

Oct 2012        Special Lecture, Society for Neuroscience (SfN), New Orleans, LA

Jun 2007         Keynote Speaker, Dutch Endo-Neuro-Psycho National Meeting, Doorwerth, NL

Symposia and Invited Oral Presentations

Sept 2019        University of Minnesota, Minneapolis, MN

June 2019     MSN 2019, Marrakech, Morocco

June 2019     OptoDBS 2019, Geneva, Switzerland

June 2019     Ernst Strüngmann Forum: Intrusive Thinking across Neuropsychiatric Disorders: From Molecules to Free Will, Frankfurt, Germany

May 2019     Perinatal Origins of Neuropsychiatric Disorders (PONDS): from Molecular Mechanisms to Therapeutic Perspectives, Palermo, Italy

April 2019    25thScientific Conference of SNIP

Feb 2019       Wake Forest School of Medicine, Winston-Salem, NC

Nov 2018     4rd Bio Forum of the Shanghai Institute of Advanced Immunochemical Studies of Shanghai Tech University, Shanghai, China

Oct 2018        Frontiers in Addiction Research and Pregnancy, Atlanta, GA

Oct 2018        University of Minnesota NIDA T32 Training Program Retreat, Minneapolis, MN

June 2018     UC Irvine Center for Addictive Neuroscience (ICAN), Irvine, CA

May 2018     83rdCold Spring Harbor Laboratory Symposium on Quantitative Biology addressing Brains & Behavior: Order & Disorder in the Nervous System, Cold Spring Harbor, NY

May 2018     Society for Biological Psychiatry (SOBP) 73rdAnnual Scientific Convention, New York, NY

May 2018     2018 American Psychiatry Association Annual Meeting, New York, NY

Mar 2018       David Geffen School of Medicine Distinguished Lectures, UCLA, Los Angeles, CA

Feb 2018        University of Massachusetts, Amherst, MA

Nov 2017       2ndAnnual Zardi Gori Foundation Conference, Milan, Italy

Oct 2017        38thNational Congress of the Italian Society of Pharmacology, Rimini, Italy

Sept 2017       Second Annual 2017 Brookstone Conference, Northwestern University, Chicago, IL

Sept 2017       Department of Molecular Biology and Genetics, University of Aarhus, Aarhus, Denmark

Sept 2017       School of Psychology, Nanjing Normal University, Nanjing, China

Sept 2017       Annual Neuroscience Conference of China, Tianjin, China

Sept 2017       Beijing University, Beijing, China

Jun 2017         Mediterranean Neuroscience society, LaValletta, Malta

May 2017      Ministry of Science and Technology, Taipei, Taiwan

May 2017      Academia Sinica, Taipei, Taiwan, Taipei, Taiwan

May 2017      National Taiwan Medical School, Taipei, Taiwan

May 2017      The 2ndInternational Taiwanese Congress of Neurology and Annual meeting of Taiwan Neurological Society, Taipei Taiwan

May 2017      Johns Hopkins Research Retreat, Baltimore, MD

May 2017      Alcoholism and Stress: A Framework for Future Treatment Strategies, Volterra, Italy

May 2017      Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Mar 2017       Study in Multidisciplinary Pain Research (SIMPAR) Florence, Italy

Mar 2017     University of Napoli Parthenope, Naples, Italy

Mar 2017     Catholic University of Rome and Gemelli Hospital, Rome, Italy

Mar 2017     National Institutes of Health and Karolinska Insitutet Joint Neuroscience Symposium, Stockholm Sweden

Mar 2017     Karolinska Insitutet Solna Campus, Stockholm, Sweden

Feb 2017        Columbia University, New York, NY

Feb 2017        University of North Carolina, Chapel Hill, NC

Nov 2016     Italian Scientist and Scholars of North American Foundation (ISSNAF), Washington, DC

Oct 2016        Universita di Camerino, Camerino (MC) Italy

Sep 2016       DECODE summitTranslating Neural Circuit Research into Transformative CNS Therapeutics, Palo Alto, CA

Sep 2016        Dopamine 2016, Vienna, Austria

Jun 2016         Brotzu Hospital, Cagliari, Italy

Jun 2016         San Camillo Hospital, Application of TMS on Drug Addiction, Venice, Italy

Apr 2016        Study in Multidisciplinary Pain Research (SIMPAR) Rome, Italy

Mar 2016       Frontiers in Pain Research, McGill University, Montreal Canada

Feb 2016        Gordon Conference on Alcoholism, Galveston, TX

Jan 2016       Neuroscience Research Colloquia, Vancouver, BC

Dec 2015      American College of Neuropsychopharmacology, Hollywood, FL

Nov 2015     Karolinska Institutet, Stockholm, Sweden

Nov 2015     Società Italiana Tossicodipendenze (SITD), Milan, Italy

Oct 2015      Department of Pharmacology, Cambridge University, Cambridge, UK

Sep 2015      The Jackson Laboratory, Bar Harbor, ME

Aug 2015     Gordon Research Conference on Catecholamine’s, Newry, ME

Aug 2015     Cold Spring Harbor, Cellular Biology of Addiction Course, Cold Spring Harbor, NY

Apr 2015     University of California Los Angeles (UCLA), Los Angeles, CA

Feb 2015      Universidad Nacional Autònoma de Mexico, Mexico City, NM

Feb 2015      Vanderbilt University, Nashville, TN

Jan 2015       Stanford Neuroscience Institute, Stanford, CA

Dec 2014      American College of Neuropsychopharmacology (ACNP), Phoenix, AZ

Nov 2014     Italian Scientist and Scholars of North American Foundation (ISSNAF), Washington, DC

Oct 2014      Servizio Sanitario Regionale, Emilia-Romagna, Rimini, Italy

Oct 2014      Liceo Scientifico Einstein, Rimini, Italy

Oct 2014      WeFree Days, San Patrignano Community, San Patrignano, Italy

Sep 2014      University of Buffalo, Buffalo, NY

Sep 2014      Massachusetts Institute of Technology, Cambridge, MA

Jun 2014        8thALBATROS Congress, International Congress of Addictology, Paris, France

Apr 2014     Pfizer, Cambridge, MA

Apr 2014     Bordeaux Neuroscience Federation, Bordeaux, France

Apr 2014     Guest Speaker at the Neuroscience Retreat, Medical University of South Carolina, Charleston, SC

Apr 2014     Harvard Medical School Department of Neurobiology Seminar, Boston, MA

Mar 2014     Inaugural Lecture, Joint Neuroscience and Clinical Neuroscience Series, Karolinska Institutet, Stockholm, Sweden

Feb 2014      Gordon Research Conference on Alcohol, Galveston, TX

Feb 2014      Cornell University, Ithaca, NY

Sep 2013      University of Puerto Rico, Santiago, PR

Aug 2013     Co-Chair, Cellular Biology of Addiction Course, Cold Spring Harbor, NY

May 2013    Universitè de Montreal, Montreal, Canada

May 2013    Congress Dopamine 2013, Alghero, Italy

Apr 2013     Yale University, New Haven, CT

Mar 2013     Study in Multidisciplinary Pain Research (SIMPAR) 5th Meeting, Pavia, Italy

Feb 2013      University of California San Francisco, San Francisco, CA

Jan 2013       Columbia University, New York, NY

Dec 2012      American College of Neuropsychopharmacology (ACNP) Annual Meeting, Hollywood, FL

Nov 2012     Karolinska Institutet, Stockholm Sweden

Sep 2012      The Tenth International Catecholamine Symposium (XICS), Pacific Grove, CA

Aug 2012     Co-Chair, Cold Spring Harbor Cell Biology of Addiction Course, Barcelona, Spain

Jun 2012      Research Society of Alcoholism (RSA), San Francisco, CA

May 2012    Taiwan Medical University, Taipei, Taiwan

May 2012    Chen Kung University, Tainan, Taiwan

Apr 2012     Stony Brook University, Stony Brook, NY

Apr 2012     Rockefeller University, New York, NY

Apr 2012     University of Maryland School of Medicine, Baltimore, MD

Apr 2012     National Institutes of Health, Demystifying Medicine Lecture Series, Bethesda, MD

Feb 2012      University of Texas at Dallas, Dallas, TX

Nov 2011     University of Medicine & Dentistry of New Jersey, Medical School Grand Rounds, Newark, NJ

Oct 2011      University of Texas, Austin, TX

Oct 2011      University of Washington, Seattle, WA

Oct 2011      Neurology Grand Rounds Johns Hopkins School of Medicine, Baltimore, MD

Sep 2011      Stanford University, Stanford, CA

Sep 2011      Johns Hopkins University (Homewood Campus) Baltimore, MD

Aug 2011     Co-Chair, Cellular Biology of Addiction Course, Cold Spring Harbor, NY

Aug 2011     Vice-Chair, Gordon Research Conference on Catecholamines, Lewiston, ME

Jun 2011      Mount Sinai School of Medicine, New York, NY

Jun 2011      The College on Problems of Drug Dependence (CPDD), Hollywood, FL

May 2011      Association of University Anesthesiologists, Philadelphia, PA

Apr 2011        New York University Medical School, New York, NY

Apr 2011     Cold Spring Harbor Laboratory, HHMI, Cold Spring Harbor, NY

Mar 2011     Georgetown University, Washington, DC

Feb 2011      University of Texas, San Antonio, TX

Jan 2011       Johns Hopkins School of Medicine, Baltimore, MD

Jan 2011       University of Texas, Austin, TX

Jan 2011       Cold Spring Harbor Laboratory, HHMI, Cold Spring, NY

Dec 2010      American College of Neuropsychopharmacology (ACNP), Miami Beach, FL

Nov 2010     Janelia Farm Research Campus Conference, Howard Hughes Medical Institute, Ashburn, VA

Nov 2010     The Ernest Gallo Clinic and Research Center, San Francisco, CA

Nov 2010     National Academy of Sciences, Japanese-American Frontiers of Science Symposium, Chiba, Japan

Sep 2010      National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD

Sep 2010      Maryland Psychiatric Research Center, Catonsville, MD

Sep 2010      National Hispanic Science Network, New Orleans, LA

May 2010    Emory University, Atlanta, GA

Apr 2010     Duke University, Durham, NC

Apr 2010     University of California San Francisco, San Francisco, CA

Mar 2010     University of Texas, Southwestern, Dallas, TX

Feb 2010      University of California at Los Angeles, Los, Angeles, CA

Dec 2009      American College of Neuropsychopharmacology (ACNP), symposium speaker, Hollywood, FL

Oct 2009      California Society on Addiction Medicine, San Francisco, CA

Oct 2009      Northwestern University, Chicago, IL

Aug 2009     Cellular Biology of Addiction Course, Cold Spring Harbor, NY

Aug 2009     Gordon Conference on Catecholamines, University of New England, Biddeford, ME

Apr 2009     University of Tennessee, Knoxville, TN

Mar 2009     Baylor College, Houston, TX

Dec 2008      American College of Neuropsychopharmacology (ACNP), Symposium Chair, Scottsdale, AZ

Aug 2008     Addiction Conference on Dopamine (co-organizer), Kunming, China

Oct 2008      Gordon Conference, Neurobiology of Brain Disorders, Oxford, England, United Kingdom

Aug 2008     Eli Lilly and Company, Indianapolis, IN

Jun 2008      University of North Carolina, Chapel Hill, NC

May 2008    Alcoholism and Stress: A Framework for Future Treatment Strategies, Volterra, Italy

Apr 2008     Aspen Meeting, San Diego, CA

Mar 2008     Rockefeller University, New York, NY

Mar 2008     University of Maryland, Adelphi, MD

Feb 2008      Yale University, New Haven, CT

Jan 2008       Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA

Dec 2007      American College of Neuropsychopharmacology (ACNP), Boca Raton, FL

Nov 2007     University of Alabama, Birmingham, AL

Oct 2007      University of California Irvine, Irvine, CA

Sep 2007      European Behavioral Pharmacology Society (EBPS) Meeting, Tübingen, Germany

Sep 2007      University of Vienna, Wien, Austria

Sep 2007      European Society for Biomedical Research on Alcoholism (ESBRA), Berlin, Germany

Jul 2007       Research Society for Alcoholism (RSA) Meeting, Chicago, IL

Jun 2007         Dutch Endo-Neuro-Psycho National Meeting, Doorwerth, NL

May 2007    DA 50th Anniversary, Gothenburg, Sweden

May 2007    VU University Amsterdam, Amsterdam, Netherlands

Apr 2007     University of Pittsburgh, Pittsburgh, PA

Mar 2007     University of Pennsylvania, Philadelphia, PA

Mar 2007     Mayo Clinic, Rochester, MN

Feb 2007      University of Minnesota, Minneapolis, MN

Dec 2006      American College of Neuropsychopharmacology (ACNP) Meeting, Hollywood, FL

Nov 2006     North America Congress of Clinical Toxicology (NACCT) Meeting, San Francisco, CA

Jun 2006      Research Society on Alcoholism (RSA) Meeting, Baltimore, MD

Apr 2006     University of Minnesota, Minneapolis, MN

Jan 2006       University of Washington, Seattle, WA

Dec 2005      University of San Antonio, San Antonio, TX

Dec 2005      Cantoblanco Workshop on Learning and Memory, Madrid, Spain

Nov 2005     National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD

Jul 2005       Gordon Conference on Catecholamines, Andover, NH

Jun 2005      The Scripps Clinic, University of California, San Diego, San Diego, CA

May 2005    Virginia Commonwealth University, Richmond, VA

May 2005    Medical University of South Carolina (MUSC), Charleston, SC

Apr 2005     Boston University, Boston, MA

Mar 2005     Loyola University, Chicago, IL

Mar 2005     Calgary University, Calgary, Canada

Dec 2004      Vanderbilt University, Memphis, TN

Nov 2004     Washington University, Seattle, WA

Oct 2004      Society for Neuroscience (SfN) Annual Meeting, NIDA Symposium on Drug Addiction, San Diego, CA

Aug 2004     Gordon Conference on Synaptic Transmission, Meriden, NH

May 2004    University of Albany, Albany, NY

Apr 2004     University of Chicago, Chicago, IL

Mar 2004     NIDA, Intramural Research Program Seminar Series, Bethesda, MD

Feb 2004      International Congress of Biological Psychiatry, Sydney, Australia

Jan 2004       Winter Conference on Brain Research, Copper Mountain, CO

Aug 2003     Gordon Conference on Catecholamines, Oxford, England, United Kingdom

Aug 2003     University of Bologna, Italy

Jul 2003       International Brain Research Organization Meeting, Prague, Czech Republic

May 2003    University of North Carolina, Chapel Hill, NC

May 2003    Wake Forest University, Winston-Salem, NC

Jan 2003       Winter Conference on Brain Research (Symposium speaker and Chair), Snowbird, UT

Dec 2002      American College of Neuropsychopharmacology (ACNP), San Juan, Puerto Rico

Dec 2002      Baylor College, Houston, TX

Nov 2002     Society for Neuroscience (SfN), Orlando, FL

Oct 2002      The Scripps Clinic, University of California at San Diego, CA

Oct 2002      Northwestern University, Chicago, IL

Sep 2002      National Institute of Mental Health (NIMH), Bethesda, MD

Sep 2002      National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD

Jun 2002      Research Society on Alcoholism (RSA), San Francisco, CA

Feb 2002      Dallas Southwestern Medical School, Dallas, TX

Feb 2002      Brown Bag Lecture, University of California San Francisco, San Francisco, CA

Jan 2002       Winter Conference on Brain Research, Snowmass, CO

Sep 2001      World Neuroinformatics Meeting, Vienna, Italy

Jun 2001      Research Society for Alcoholism (RSA), Montreal, Canada

Apr 2001     Brain Science Institute, Riken, Japan

Mar 2001     Frontiers in Neurology and Neuroscience, University of California San Francisco, San Francisco, CA

Jan 2001       Winter Conference on Brain Research, Steamboat Springs, CO

May 2000    Karolinska Institute, Stockholm, Sweden

Mar 2000     Oregon Health Science University, Portland, OR

Feb 2000      University of Bologna, Bologna, Italy

Dec 1999      Gladstone Institute, University of California San Francisco, San Francisco, CA

Jul 1999       Gordon Conferences on Catecholamines, Queen’s College Oxford, UK


Director, Optogenetic Core, Ernest Gallo Clinic and Research Center

Member, Executive Committee, Ernest Gallo Clinic and Research Center

Member, Wheeler Center for the Neurobiology of Drug Addiction, UCSF

Member, Preclinical Development Committee, Gallo Center

Member, Memory and Aging Clinic, UCSF

Member, Student Merit Committee, UCSF

Member, MD with Thesis Committee, UCSF

Chair, Committee on Animal Use, Department of Neurology 


Member, Scientific Director Search Committee, National Center for Complementary and Alternative Medicine

Member, Senior Biomedical Research Service Policy Board

Member, National Institute on Alcohol Abuse and Alcoholism, Laboratory of Clinical and Translational Studies Search Committee

Member, Scientific Director Agenda Subcommittee

Member, Promoting the IRP Subcommittee

Member, Shared Resources Subcommittee

Member, Scientific Directors Search Committee, National Institute of Mental Health

Member, Clinical Search Committee, National Institute of Neurological Disorders and Stroke

Member, Facilities Working Group Committee

Co-Chair, NIH Research Festival

Chair, NIDA DBCBR Director Search Committee

Member, Center for Scientific Review (CSR/NIH), Grant Review

Member, 2014-2017Administrative Strategic Plan Initiative

Member, 2015-2017 NIDA’s HIV/AIDS Research Working Group, National Institute on Drug Abuse, Nation Advisory Council on Drug Abuse


– US 60/491,069:  Modulation of CRF Potentiation of NMDA Receptor Currents via CRF Receptor 2

– US 10/903,849:   Modulation of CRF Potentiation of NMDA Receptor Currents via CRF Receptor 2

– US 60/460,270:  Modulating Cooperative Activity of Dopamine D1 and D2 Receptors to Mitigate                    Substance Abuse

– US 10/818,709:  Modulating Cooperative Activity of Dopamine D1 and D2 Receptors to Mitigate Substance Abuse

– US 60/757,821:  Use of SK Channel Activators to Prevent Relapse/ Reinstatement of Drugs of Abuse

– PCT/US07/00308: Use of SK Channel Activators to Prevent Relapse/ Reinstatement of Drugs of Abuse

– US 60/647,748: Modulation of NMDA Receptor Currents via Orexin Receptor and/or CRF Receptors

– US 11/343,259: Modulation of NMDA Receptor Currents via Orexin Receptor and/or CRF Receptor

– PCT/US06/03133: Modulation of NMDA Receptor Currents via Orexin Receptor and/or CRF Receptor

– US 61/166,632:  Chimera Compositions and Uses Thereof

– US 61,182,032:  Chimera Compositions and Uses Thereof

TEACHING (formal)

Fall 1996                    Guest Lecturer, Neurophysiology and Neurochemistry, School of Physiotherapy,

Rome University, (~22 Students) 7 hours

Fall 1997                    Guest Lecturer, Physiology of Basal Ganglia, School of Physiotherapy,

Rome University, (~24 Students) 6 hours

Spring 2000                Guest Lecturer, Neurobiology of Addiction Course (N263), UCSF – (20 students)

April 6, 2000 – Physiology of mesolimbocortical dopamine pathway, 2 hours

April 11, 2000 – Paper discussion on mesolimbic dopamine system, 2 hours

2003 -2006                 Group Leader, Brain, Mind and Behavior, UCSF (10-15 Students) 20 hours/year

2006                           Guest Lecturer, Neuroscience 201A course, UCSF (~12 Students) 15 hours/year

2007-2010                  Guest Lecturer, Memory and Aging Center, UCSF (40 – 50 Students) 30 hours/year

2009                           Group Leader, Brain, Mind and Behavior, UCSF (~12 Students) 20 hours/year

2011                           Adjunct Professor, Neurobiology of Substance Abuse Disorders, John Hopkins

University (JHU) (20 Students) 1 hour

2012-Present              Adjunct Professor, Novel Approaches to Studying Drug Abuse in Synaptic Plasticity,

JHU (~20 students) 2 hours/Year

2012-Present             Adjunct Professor, NIDA IRP and John Hopkins Neuroscience Course,

Neurobiology of Substance abuse Disorders, lecture, JHU (~20 students) 1 hour

2007-Present       Course Co-Chair, Current Topics in Neuroscience, JHU

Neuroscience Graduate Program, (6 students) 40 hours/year

2011-PresentGuest Lecturer, Lecture on Reward, Conditioning, and Drug Abuse, Georgetown

University, (~20 students) 1 hour

2014                          Guest Lecturer, Summer School Cortona, Lecture, Tuscany (~20 Students) 4 hours

2015                           Guest Lecturer, Catholic University of Sacred Heart, Italy (~50 students)

2016                           Neuroscience School of Advanced Studies (NSAS) Course, Tuscany (~20 students)

Spring 2018         Adjunct Professor, Neurobiology of Drug Abuse, Master’s Program in integrative Neuroscience, Georgetown University, (~20 students)

Summer 2018       Guest Lecturer, Neuroscience School of Advanced Studies (NSAS), Venice (~20 students)


All grants have been terminated as of Aug 29, 2010

5 R01 DA015096-07(Bonci) 04/15/07 – 11/30/11, 3.30 calendar months, NIH/NIDA, $176,400                      (27.5% effort)

Synaptic Plasticity in the VTA after Behavioral Sensitization & Cocaine Self-administration

The major goal of this project is to elucidate the relationship between plasticity at excitatory synapses in the ventral tegmental area (VTA) and addictive behaviors such as behavioral sensitization and self-administration of cocaine.

2 R01 DA016782-05A1    07/01/09 – 06/30/14, 3 calendar months, NIH/NIDA, $225,335

(25% effort)

CRF Modulation of NMDA Currents and Behavior in the VTA

The major goal of this project is to elucidate the role of CRFR1 and CRFR2 in promoting stress-enhanced relapse to cocaine seeking.

N/A (Selena/Bonci/EGCRC), 04/01/09 – 03/31/10, 60 calendar months, UCSF Dept. of

Neurology, $100,000

(5% effort)

Corticotropin-releasing Factor-binding Protein (CRF-BP)

The major goal of this project is to study the role of corticotrophin-releasing factor binding protein and how it is related to medications development.

1 RC2 AA019429-01, 10/01/09 – 09/30/11, 1.2 calendar months, NIH/NIDA,     $756,151                               (10% effort)

Characterizing Alpha 5* Nicotinic Receptors in Alcohol and Nicotine Co-Dependence

The major goal of this project is to accelerate the development of more effective medications and to improve and personalize treatment strategies for substance use disorders.

Log No. 09044003(Bartlett/Bonci), 10/01/09 – 09/30/10, 1.2 calendar months.

U.S. Department of the Army, $201,883

(10 % effort)

Neurobiology of Relapse:  The Role of Orexin Receptors

The main objective of this project is to determine whether therapies that combine orexin antagonists and PKC inhibitors would be of greater utility as therapeutic interventions for stress-dependent disorders and alcoholism.

R01 AA026589(PI: Sheffler; Subaward PI: Haass-Koffler)

NIH/NIAAA 05/01/2019 – 03/31/2022 ($865,843)

Lead optimization of novel CRFBP-CRFR2 complex modulators for alcohol use disorder

This project will develop CRF-BP/CRFR2 negative allosteric modulators (NAMs) using structure activity relationship (SAR) and electrophysiology for treating Alcohol Use Disorder  

Peer-reviewed Publications 

  1. Troiani D, Draicchio F, Bonci A, Zannoni B. Responses of vestibular neurons to stimulation of cortical sensorimotor areas in the cat. Arch Ital Biol. 1993 Apr;131(2-3):137-46. PubMed PMID: 8338385.
  2. Mercuri NB, Stratta F, Calabresi P, Bonci A, Bernardi G. Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons. Neuroscience. 1993 Sep;56(2):399-407. PubMed PMID: 7504216.
  3. Carlesimo GA, Fadda L, Bonci A, Caltagirone C. Differential rates of forgetting from long-term memory in Alzheimer’s and multi-infarct dementia. Int J Neurosci. 1993 Nov;73(1-2):1-11. PubMed PMID: 8132410.
  4. Mercuri NB, Bonci A, Johnson SW, Stratta F, Calabresi P, Bernardi G. Effects of anoxia on rat midbrain dopamine neurons. J Neurophysiol. 1994 Mar;71(3):1165-73. PubMed PMID: 8201410.
  5. Mercuri NB, Bonci A, Calabresi P, Stratta F, Stefani A, Bernardi G. Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones. Br J Pharmacol. 1994 Nov;113(3):831-8. PubMed PMID: 7858874; PubMed Central PMCID: PMC1510432.
  6. Mercuri NB, Bonci A, Calabresi P, Stratta F, Bernardi G. Responses of rat mesencephalic dopaminergic neurons to a prolonged period of oxygen deprivation. Neuroscience. 1994 Dec;63(3):757-64. PubMed PMID: 7898675.
  7. Stefani A, Pisani A, Bernardi G, Bonci A, Mercuri NB, Stratta F, Calabresi P. The modulation of dopamine receptors in rat striatum. J Neural Transm Suppl. 1995;45:61-6. Review. PubMed PMID: 8748610.
  8. Stratta F, Bonci A, Calabresi P, Stefani A, Pisani A, Bernardi G, Mercuri NB. Basic research in substantia nigra and ventral tegmental area: clinical implications. J Neural Transm Suppl. 1995;45:47-55. Review. PubMed PMID: 8748608.
  9. Mercuri NB, Bonci A, Calabresi P, Stefani A, Bernardi G. Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. Eur J Neurosci. 1995 Mar 1;7(3):462-9. PubMed PMID: 7773443.
  10. Stefani A, Pisani A, Bonci A, Stratta F, Bernardi G. Outward potassium currents activated by depolarization in rat globus pallidus. Synapse. 1995 Jun;20(2):131-6. PubMed PMID: 7570342.
  11. Stefani A, De Murtas M, Pisani A, Stratta F, Bonci A, Mercuri NB, Calabresi P. Electrophysiology of dopamine D-1 receptors in the basal ganglia: old facts and new perspectives. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Sep;19(5):779-93. Review. PubMed PMID: 8539419.
  12. Mercuri NB, Bonci A, Pisani A, Calabresi P, Bernardi G. Actions of glycine on non-dopaminergic neurons of the rat substantia nigra. Eur J Neurosci. 1995 Nov 1;7(11):2351-4. PubMed PMID: 8563984.
  13. Mercuri NB, Bonci A, Siniscalchi A, Stefani A, Calabresi P, Bernardi G. Electrophysiological effects of monoamine oxidase inhibition on rat midbrain dopaminergic neurones: an in vitro study. Br J Pharmacol. 1996 Feb;117(3):528-532. PubMed PMID: 8821544; PubMed Central PMCID: PMC1909293.
  14. Bonci A, Williams JT. A common mechanism mediates long-term changes in synaptic transmission after chronic cocaine and morphine. Neuron. 1996 Mar;16(3):631-9. PubMed PMID: 8785060.
  15. Mercuri NB, Bonci A, Calabresi P, Bernardi G. Characterization of a barium-sensitive outward current following glutamate application on rat midbrain dopaminergic cells. Eur J Neurosci. 1996 Aug;8(8):1780-6. PubMed PMID: 8921268.
  16. Siniscalchi A, Bonci A, Mercuri NB, Bernardi G. Effects of riluzole on rat cortical neurones: an in vitro electrophysiological study. Br J Pharmacol. 1997 Jan;120(2):225-30. PubMed PMID: 9117114; PubMed Central PMCID: PMC1564377.
  17. Bonci A, Williams JT. Increased probability of GABA release during withdrawal from morphine. J Neurosci. 1997 Jan 15;17(2):796-803. PubMed PMID: 8987801.
  18. Mercuri NB, Scarponi M, Bonci A, Siniscalchi A, Bernardi G. Monoamine oxidase inhibition causes a long-term prolongation of the dopamine-induced responses in rat midbrain dopaminergic cells. J Neurosci. 1997 Apr 1;17(7):2267-72. PubMed PMID: 9065488.
  19. Mercuri NB, Bonci A, Bernardi G. Electrophysiological pharmacology of the autoreceptor-mediated responses of dopaminergic cells to antiparkinsonian drugs. Trends Pharmacol Sci. 1997 Jul;18(7):232-5. Review. PubMed PMID: 9253853.
  20. Mercuri NB, Saiardi A, Bonci A, Picetti R, Calabresi P, Bernardi G, Borrelli E. Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice. Neuroscience. 1997 Jul;79(2):323-7. PubMed PMID: 9200717.
  21. Bonci A, Grillner P, Siniscalchi A, Mercuri NB, Bernardi G. Glutamate metabotropic receptor agonists depress excitatory and inhibitory transmission on rat mesencephalic principal neurons. Eur J Neurosci. 1997 Nov;9(11):2359-69. PubMed PMID: 9464930.
  22. Fiorillo CD, Williams JT, Bonci A. D1-receptor regulation of synaptic potentials in the ventral tegmental area after chronic drug treatment. Adv Pharmacol. 1998;42:1002-5. PubMed PMID: 9328067.
  23. Mercuri NB, Scarponi M, Federici M, Bonci A, Siniscalchi A, Bernardi G. Modification of levodopa responses by deprenyl (selegiline): an electrophysiological and behavioral study in the rat relevant to Parkinson’s disease. Ann Neurol. 1998 May;43(5):613-7. PubMed PMID: 9585355.
  24. Bonci A, Grillner P, Mercuri NB, Bernardi G. L-Type calcium channels mediate a slow excitatory synaptic transmission in rat midbrain dopaminergic neurons. J Neurosci. 1998 Sep 1;18(17):6693-703. PubMed PMID: 9712641.
  25. Grillner P, Bonci A, Svensson TH, Bernardi G, Mercuri NB. Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon. Neuroscience. 1999;91(2):557-65. PubMed PMID: 10366013.
  26. Bonci A, Malenka RC. Properties and plasticity of excitatory synapses on dopaminergic and GABAergic cells in the ventral tegmental area. J Neurosci. 1999 May 15;19(10):3723-30. PubMed PMID: 10234004.
  27. Thomas MJ, Malenka RC, Bonci A. Modulation of long-term depression by dopamine in the mesolimbic system. J Neurosci. 2000 Aug 1;20(15):5581-6. PubMed PMID: 10908594.
  28. Ungless MA, Whistler JL, Malenka RC, Bonci A. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature. 2001 May 31;411(6837):583-7. PubMed PMID: 11385572.
  29. Thomas MJ, Beurrier C, Bonci A, Malenka RC. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat Neurosci. 2001 Dec;4(12):1217-23. PubMed PMID: 11694884.
  30. Melis M, Camarini R, Ungless MA, Bonci A. Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. J Neurosci. 2002 Mar 15;22(6):2074-82. PubMed PMID: 11896147.
  31. Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5710-5. Epub 2002 Apr 9. PubMed PMID: 11943848; PubMed Central PMCID: PMC122836.
  32. Saal D, Dong Y, Bonci A, Malenka RC. Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron. 2003 Feb 20;37(4):577-82. Erratum in: Neuron. 2003 Apr 24;38(2):359. PubMed PMID: 12597856.
  33. Bonci A, Bernardi G, Grillner P, Mercuri NB. The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction? Trends Pharmacol Sci. 2003 Apr;24(4):172-7. Review. PubMed PMID: 12707003.
  34. Hopf FW, Cascini MG, Gordon AS, Diamond I, Bonci A. Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits. J Neurosci. 2003 Jun 15;23(12):5079-87. PubMed PMID: 12832531.
  35. Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron. 2003 Jul 31;39(3):401-7. PubMed PMID: 12895416.
  36. Margolis EB, Hjelmstad GO, Bonci A, Fields HL. Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons. J Neurosci. 2003 Nov 5;23(31):9981-6. PubMed PMID: 14602811.
  37. Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, Bargmann CI, McIntire SL. A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell. 2003 Dec 12;115(6):655-66. PubMed PMID: 14675531.
  38. Chandler LJ, Bonci A, Wand GS, Morrisett RA. Recent advances in cyclic-adenosine monophosphate/protein kinase A signaling in ethanol-induced synaptic and behavioral alterations. Alcohol Clin Exp Res. 2004 Jul;28(7):1129-36. PubMed PMID: 15252301.
  39. Choi DS, Cascini MG, Mailliard W, Young H, Paredes P, McMahon T, Diamond I, Bonci A, Messing RO. The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci. 2004 Aug;7(8):855-61. Epub 2004 Jul 18. PubMed PMID: 15258586.
  40. Borgland SL, Malenka RC, Bonci A. Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. J Neurosci. 2004 Aug 25;24(34):7482-90. PubMed PMID: 15329395.
  41. Dong Y, Saal D, Thomas M, Faust R, Bonci A, Robinson T, Malenka RC. Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) mice. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14282-7. Epub 2004 Sep 16. PubMed PMID: 15375209; PubMed Central PMCID: PMC521147.
  42. Hopf FW, Mailliard WS, Gonzalez GF, Diamond I, Bonci A. Atypical protein kinase C is a novel mediator of dopamine-enhanced firing in nucleus accumbens neurons. J Neurosci. 2005 Jan 26;25(4):985-9. PubMed PMID: 15673680.
  43. Jones S, Bonci A. Synaptic plasticity and drug addiction. Curr Opin Pharmacol. 2005 Feb;5(1):20-5. Review. PubMed PMID: 15661621.
  44. Margolis EB, Hjelmstad GO, Bonci A, Fields HL. Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons. J Neurophysiol. 2005 Jun;93(6):3086-93. Epub 2004 Dec 22. PubMed PMID: 15615834.
  45. Bonci A, Hopf FW. The dopamine D2 receptor: new surprises from an old friend. Neuron. 2005 Aug 4;47(3):335-8. Review. PubMed PMID: 16055058.
  46. Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11521-6. Epub 2005 Jul 27. PubMed PMID: 16049099; PubMed Central PMCID: PMC1183554.
  47. Suvarna N, Borgland SL, Wang J, Phamluong K, Auberson YP, Bonci A, Ron D. Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem. 2005 Sep 9;280(36):31450-9. Epub 2005 Jul 11. PubMed PMID: 16009711.
  48. Bonci A, Carlezon WA Jr. Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disorders. Pharmacol Ther. 2005 Oct;108(1):65-75. Review. PubMed PMID: 16095714.
  49. Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A. Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron. 2006 Feb 16;49(4):589-601. PubMed PMID: 16476667.
  50. Bonci A, Singh V. Dopamine dysregulation syndrome in Parkinson’s disease patients: from reward to penalty. Ann Neurol. 2006 May;59(5):733-4. PubMed PMID: 16634013.
  51. Martin M, Chen BT, Hopf FW, Bowers MS, Bonci A. Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens. Nat Neurosci. 2006 Jul;9(7):868-9. Epub 2006 May 28. PubMed PMID: 16732275.
  52. Schilström B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D, Bonci A. Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors.J Neurosci. 2006 Aug 16;26(33):8549-58. Erratum in: J Neurosci. 2006 Sep 13;26(37):9604. PubMed PMID: 16914681.
  53. Inoue Y, Yao L, Hopf FW, Fan P, Jiang Z, Bonci A, Diamond I. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):23-9. Epub 2007 Apr 27. PubMed PMID: 17468300.
  54. Sarti F, Borgland SL, Kharazia VN, Bonci A. Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area. Eur J Neurosci. 2007 Aug;26(3):749-56. PubMed PMID: 17686047.
  55. Singh V, Carman M, Roeper J, Bonci A. Brief ischemia causes long-term depression in midbrain dopamine neurons. Eur J Neurosci. 2007 Sep;26(6):1489-99. PubMed PMID: 17880389.
  56. Hopf FW, Martin M, Chen BT, Bowers MS, Mohamedi MM, Bonci A. Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro. J Neurophysiol. 2007 Oct;98(4):2297-310. Epub 2007 Aug 15. PubMed PMID: 17699688.
  57. Bowers MS, Chen BT, Chou JK, Osborne MP, Gass JT, See RE, Bonci A, Janak PH, Olive MF. Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2007 Dec;195(3):397-406. Epub 2007 Sep 2. PubMed PMID: 17764007.
  58. Wanat MJ, Hopf FW, Stuber GD, Phillips PE, Bonci A. Corticotropin-releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C-dependent enhancement of Ih. J Physiol. 2008 Apr 15;586(Pt 8):2157-70. doi: 10.1113/jphysiol.2007.150078. Epub 2008 Feb 28. PubMed PMID: 18308824; PubMed Central PMCID: PMC2465205.
  59. Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature. 2008 Jun 26;453(7199):1253-7. doi: 10.1038/nature06963. Epub 2008 May 11. PubMed PMID: 18469802; PubMed Central PMCID: PMC2759353.
  60. Richards JK, Simms JA, Steensland P, Taha SA, Borgland SL, Bonci A, Bartlett SE. Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl). 2008 Jul;199(1):109-17. doi: 10.1007/s00213-008-1136-5. Epub 2008 May 10. PubMed PMID: 18470506; PubMed Central PMCID: PMC2668563.
  61. Chen BT, Bowers MS, Martin M, Hopf FW, Guillory AM, Carelli RM, Chou JK, Bonci A. Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. Neuron. 2008 Jul 31;59(2):288-97. doi: 10.1016/j.neuron.2008.05.024. PubMed PMID: 18667156; PubMed Central PMCID: PMC2593405.
  62. Zweifel LS, Argilli E, Bonci A, Palmiter RD. Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron. 2008 Aug 14;59(3):486-96. doi: 10.1016/j.neuron.2008.05.028. PubMed PMID: 18701073; PubMed Central PMCID: PMC2556153.
  63. Bowers MS, Hopf FW, Chou JK, Guillory AM, Chang SJ, Janak PH, Bonci A, Diamond I. Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12533-8. doi: 10.1073/pnas.0706999105. Epub 2008 Aug 21. PubMed PMID: 18719114; PubMed Central PMCID: PMC2527946.
  64. Argilli E, Sibley DR, Malenka RC, England PM, Bonci A. Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. J Neurosci. 2008 Sep 10;28(37):9092-100. doi: 10.1523/JNEUROSCI.1001-08.2008. PubMed PMID: 18784289; PubMed Central PMCID: PMC2586328.
  65. Stuber GD, Klanker M, de Ridder B, Bowers MS, Joosten RN, Feenstra MG, Bonci A. Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science. 2008 Sep 19;321(5896):1690-2. doi: 10.1126/science.1160873. PubMed PMID: 18802002; PubMed Central PMCID: PMC2613864.
  66. Stuber GD, Hopf FW, Hahn J, Cho SL, Guillory A, Bonci A. Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area. Alcohol Clin Exp Res. 2008 Oct;32(10):1714-20. doi: 10.1111/j.1530-0277.2008.00749.x. Epub 2008 Jul 8. PubMed PMID: 18627359; PubMed Central PMCID: PMC3040033.
  67. Wanat MJ, Bonci A. Dose-dependent changes in the synaptic strength on dopamine neurons and locomotor activity after cocaine exposure. Synapse. 2008 Oct;62(10):790-5. doi: 10.1002/syn.20546. PubMed PMID: 18655120.
  68. Borgland SL, Storm E, Bonci A. Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. Eur J Neurosci. 2008 Oct;28(8):1545-56. doi: 10.1111/j.1460-9568.2008.06397.x. Epub 2008 Sep 10. PubMed PMID: 18793323.
  69. Bonci A, Borgland S. Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system. Neuropharmacology. 2009;56 Suppl 1:107-11. doi: 10.1016/j.neuropharm.2008.07.024. Epub 2008 Jul 24. Review. PubMed PMID: 18694770.
  70. Hopf FW, Bonci A. Striatal-enriched protein-tyrosine-phosphatase, synaptic plasticity, and psychostimulant-induced stereotypies. Biol Psychiatry. 2009 Apr 15;65(8):635-6. doi: 10.1016/j.biopsych.2009.02.008. PubMed PMID: 19328273.
  71. Wanat MJ, Sparta DR, Hopf FW, Bowers MS, Melis M, Bonci A. Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. Biol Psychiatry. 2009 Apr 15;65(8):646-53. doi: 10.1016/j.biopsych.2008.10.042. Epub 2008 Dec 31. PubMed PMID: 19118821; PubMed Central PMCID: PMC3040034.
  72. Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O. The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6772-7. doi: 10.1073/pnas.0811331106. Epub 2009 Apr 2. PubMed PMID: 19342492; PubMed Central PMCID: PMC2672513.
  73. Hahn J, Hopf FW, Bonci A. Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J Neurosci. 2009 May 20;29(20):6535-44. doi: 10.1523/JNEUROSCI.4773-08.2009. PubMed PMID: 19458224; PubMed Central PMCID: PMC3077990.
  74. Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science. 2009 May 22;324(5930):1080-4. doi: 10.1126/science.1168878. Epub 2009 Apr 23. PubMed PMID: 19389999.
  75. Abdallah L, Bonasera SJ, Hopf FW, O’Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009 Jun 24;29(25):8156-65. doi: 10.1523/JNEUROSCI.3905-08.2009. PubMed PMID: 19553455; PubMed Central PMCID: PMC3077993.
  76. Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ. Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res. 2009 Jul;33(7):1125-35. doi: 10.1111/j.1530-0277.2009.00936.x. Epub 2009 Apr 9. Review. PubMed PMID: 19389201; PubMed Central PMCID: PMC2760381.
  77. Borgland SL, Chang SJ, Bowers MS, Thompson JL, Vittoz N, Floresco SB, Chou J, Chen BT, Bonci A. Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J Neurosci. 2009 Sep 9;29(36):11215-25. doi: 10.1523/JNEUROSCI.6096-08.2009. PubMed PMID: 19741128; PubMed Central PMCID: PMC2771749.
  78. Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci. 2010;3:3-27. doi: 10.1007/7854_2009_23. Review. PubMed PMID: 21161748.
  79. Chen BT, Hopf FW, Bonci A. Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci. 2010 Feb;1187:129-39. doi: 10.1111/j.1749-6632.2009.05154.x. Review. PubMed PMID: 20201850; PubMed Central PMCID: PMC2886008.
  80. Borgland SL, Ungless MA, Bonci A. Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction. Brain Res. 2010 Feb 16;1314:139-44. doi: 10.1016/j.brainres.2009.10.068. Epub 2009 Nov 3. Review. PubMed PMID: 19891960.
  81. Madhavan A, He L, Stuber GD, Bonci A, Whistler JL. micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J Neurosci. 2010 Mar 3;30(9):3276-86. doi: 10.1523/JNEUROSCI.4634-09.2010. PubMed PMID: 20203187; PubMed Central PMCID: PMC2943338.
  82. Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron. 2010 Mar 11;65(5):682-94. doi: 10.1016/j.neuron.2010.02.015. PubMed PMID: 20223203; PubMed Central PMCID: PMC2847608.
  83. Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A. Methylphenidate facilitates learning-induced amygdala plasticity. Nat Neurosci. 2010 Apr;13(4):475-81. doi: 10.1038/nn.2506. Epub 2010 Mar 7. PubMed PMID: 20208527; PubMed Central PMCID: PMC2988577.
  84. Hopf FW, Seif T, Mohamedi ML, Chen BT, Bonci A. The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci. 2010 Jun;31(11):1946-59. doi: 10.1111/j.1460-9568.2010.07231.x. Epub 2010 May 24. PubMed PMID: 20497469; PubMed Central PMCID: PMC3077989.
  85. Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci. 2010 Jun 16;30(24):8229-33. doi: 10.1523/JNEUROSCI.1754-10.2010. PubMed PMID: 20554874; PubMed Central PMCID: PMC2918390.
  86. Kapfhamer D, Berger KH, Hopf FW, Seif T, Kharazia V, Bonci A, Heberlein U. Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci. 2010 Jun 30;30(26):8830-40. doi: 10.1523/JNEUROSCI.1292-10.2010. PubMed PMID: 20592205; PubMed Central PMCID: PMC3842471.
  87. Bowers MS, Chen BT, Bonci A. AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future. Neuron. 2010 Jul 15;67(1):11-24. doi: 10.1016/j.neuron.2010.06.004. Review. PubMed PMID: 20624588; PubMed Central PMCID: PMC2904302.
  88. Hopf FW, Bonci A. Dnmt3a: addiction’s molecular forget-me-not? Nat Neurosci. 2010 Sep;13(9):1041-3. doi: 10.1038/nn0910-1041. PubMed PMID: 20740031.
  89. Hopf FW, Chang SJ, Sparta DR, Bowers MS, Bonci A. Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res. 2010 Sep 1;34(9):1565-73. doi: 10.1111/j.1530-0277.2010.01241.x. Epub 2010 Jun 25. PubMed PMID: 20586757; PubMed Central PMCID: PMC2997761.
  90. Madhavan A, Bonci A, Whistler JL. Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci. 2010 Oct 20;30(42):14029-35. doi: 10.1523/JNEUROSCI.3366-10.2010. PubMed PMID: 20962224; PubMed Central PMCID: PMC3637958.
  91. Ungless MA, Argilli E, Bonci A. Effects of stress and aversion on dopamine neurons: implications for addiction. Neurosci Biobehav Rev. 2010 Nov;35(2):151-6. doi: 10.1016/j.neubiorev.2010.04.006. Epub 2010 May 8. Review. PubMed PMID: 20438754.
  92. Hopf FW, Sparta DR, Bonci A. Translational models of interactions between stress and alcohol consumption: strengths and limitations. ILAR J. 2011;52(3):239-50. doi: 10.1093/ilar.52.3.239. PubMed PMID: 23382142.
  93. Hopf FW, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry. 2011 Apr 1;69(7):618-24. doi: 10.1016/j.biopsych.2010.11.011. Epub 2010 Dec 31. PubMed PMID: 21195386; PubMed Central PMCID: PMC3062269.
  94. Zweifel LS, Fadok JP, Argilli E, Garelick MG, Jones GL, Dickerson TM, Allen JM, Mizumori SJ, Bonci A, Palmiter RD. Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nat Neurosci. 2011 May;14(5):620-6. doi: 10.1038/nn.2808. Epub 2011 Apr 17. PubMed PMID: 21499253; PubMed Central PMCID: PMC3083461.
  95. Stuber GD, Sparta DR, Stamatakis AM, van Leeuwen WA, Hardjoprajitno JE, Cho S, Tye KM, Kempadoo KA, Zhang F, Deisseroth K, Bonci A. Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature. 2011 Jun 29;475(7356):377-80. doi: 10.1038/nature10194. PubMed PMID: 21716290; PubMed Central PMCID: PMC3775282.
  96. Hopf FW, Seif T, Bonci A. The SK channel as a novel target for treating alcohol use disorders. Channels (Austin). 2011 Jul-Aug;5(4):289-92. doi: 10.4161/chan.5.4.16577. Epub 2011 Jul 1. PubMed PMID: 21712648.
  97. Adamantidis AR, Tsai HC, Boutrel B, Zhang F, Stuber GD, Budygin EA, Touriño C, Bonci A, Deisseroth K, de Lecea L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci. 2011 Jul 27;31(30):10829-35. doi: 10.1523/JNEUROSCI.2246-11.2011. PubMed PMID: 21795535; PubMed Central PMCID: PMC3171183.
  98. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011 Jul 28;71(2):278-90. doi: 10.1016/j.neuron.2011.05.036. PubMed PMID: 21791287; PubMed Central PMCID: PMC3417347.
  99. Seif T, Makriyannis A, Kunos G, Bonci A, Hopf FW. The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. Neuroscience. 2011 Oct 13;193:21-33. doi: 10.1016/j.neuroscience.2011.07.055. Epub 2011 Jul 27. PubMed PMID: 21821098; PubMed Central PMCID: PMC3579619.
  • Britt JP, McDevitt RA, Bonci A. Use of channelrhodopsin for activation of CNS neurons. Curr Protoc Neurosci. 2012;Chapter 2:Unit2.16. doi: 10.1002/0471142301.ns0216s58. PubMed PMID: 23042500; PubMed Central PMCID: PMC3466483.
  • Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE. The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One. 2012;7(9):e44726. doi: 10.1371/journal.pone.0044726. Epub 2012 Sep 21. PubMed PMID: 23028593; PubMed Central PMCID: PMC3448615.
  • Addolorato G, Leggio L, Hopf FW, Diana M, Bonci A. Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology. 2012 Jan;37(1):163-77. doi: 10.1038/npp.2011.216. Epub 2011 Oct 26. Review. PubMed PMID: 22030714; PubMed Central PMCID: PMC3238087.
  • Güler AD, Rainwater A, Parker JG, Jones GL, Argilli E, Arenkiel BR, Ehlers MD, Bonci A, Zweifel LS, Palmiter RD. Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nat Commun. 2012 Mar 20;3:746. doi: 10.1038/ncomms1749. PubMed PMID: 22434189; PubMed Central PMCID: PMC3592340.
  • Morales M, Bonci A. Getting to the core of addiction: Hooking CB2 receptor into drug abuse? Nat Med. 2012 Apr 5;18(4):504-5. doi: 10.1038/nm.2722. PubMed PMID: 22481411.
  1. Stuber GD, Britt JP, Bonci A. Optogenetic modulation of neural circuits that underlie reward seeking. Biol Psychiatry. 2012 Jun 15;71(12):1061-7. doi: 10.1016/j.biopsych.2011.11.010. Epub 2011 Dec 22. Review. PubMed PMID: 22196983; PubMed Central PMCID: PMC3332148.
  • Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012 Jun 27;32(26):9023-34. doi: 10.1523/JNEUROSCI.0918-12.2012. PubMed PMID: 22745501; PubMed Central PMCID: PMC3752062.
  • Tai LH, Lee AM, Benavidez N, Bonci A, Wilbrecht L. Transient stimulation of distinct subpopulations of striatal neurons mimics changes in action value. Nat Neurosci. 2012 Sep;15(9):1281-9. doi: 10.1038/nn.3188. Epub 2012 Aug 19. PubMed PMID: 22902719; PubMed Central PMCID: PMC3951287.
  • Britt JP, Benaliouad F, McDevitt RA, Stuber GD, Wise RA, Bonci A. Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens. Neuron. 2012 Nov 21;76(4):790-803. doi: 10.1016/j.neuron.2012.09.040. PubMed PMID: 23177963; PubMed Central PMCID: PMC3607383.
  • Kourrich S, Su TP, Fujimoto M, Bonci A. The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci. 2012 Dec;35(12):762-71. doi: 10.1016/j.tins.2012.09.007. Epub 2012 Oct 23. Review. PubMed PMID: 23102998; PubMed Central PMCID: PMC3587126.
  • Kravitz AV, Bonci A. Optogenetics, physiology, and emotions. Front Behav Neurosci. 2013 Nov 19;7:169. doi: 10.3389/fnbeh.2013.00169. eCollection 2013. PubMed PMID: 24312032; PubMed Central PMCID: PMC3833017.
  • Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE. The ?5 subunit regulates the expression and function of ?4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One. 2013 Jul 15;8(7):e68300. doi: 10.1371/journal.pone.0068300. Print 2013. PubMed PMID: 23869214; PubMed Central PMCID: PMC3712017.
  • Kourrich S, Hayashi T, Chuang JY, Tsai SY, Su TP, Bonci A. Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine. Cell. 2013 Jan 17;152(1-2):236-47. doi: 10.1016/j.cell.2012.12.004. PubMed PMID: 23332758; PubMed Central PMCID: PMC4159768.
  • Marchant NJ, Khuc TN, Pickens CL, Bonci A, Shaham Y. Context-induced relapse to alcohol seeking after punishment in a rat model. Biol Psychiatry. 2013 Feb 1;73(3):256-62. doi: 10.1016/j.biopsych.2012.07.007. Epub 2012 Aug 9. PubMed PMID: 22883434; PubMed Central PMCID: PMC3517691.
  • Wanat MJ, Bonci A, Phillips PE. CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors. Nat Neurosci. 2013 Apr;16(4):383-5. doi: 10.1038/nn.3335. Epub 2013 Feb 17. PubMed PMID: 23416448; PubMed Central PMCID: PMC3609940.
  • Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A. Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature. 2013 Apr 18;496(7445):359-62. doi: 10.1038/nature12024. Epub 2013 Apr 3. PubMed PMID: 23552889.
  • Kempadoo KA, Tourino C, Cho SL, Magnani F, Leinninger GM, Stuber GD, Zhang F, Myers MG, Deisseroth K, de Lecea L, Bonci A. Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. J Neurosci. 2013 May 1;33(18):7618-26. doi: 10.1523/JNEUROSCI.2588-12.2013. PubMed PMID: 23637156; PubMed Central PMCID: PMC3865559.
  • Madhavan A, Argilli E, Bonci A, Whistler JL. Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci. 2013 Jul 24;33(30):12329-36. doi: 10.1523/JNEUROSCI.0809-13.2013. PubMed PMID: 23884939; PubMed Central PMCID: PMC3721842.
  • Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug;16(8):1094-100. doi: 10.1038/nn.3445. Epub 2013 Jun 30. PubMed PMID: 23817545; PubMed Central PMCID: PMC3939030.
  • Britt JP, Bonci A. Optogenetic interrogations of the neural circuits underlying addiction. Curr Opin Neurobiol. 2013 Aug;23(4):539-45. doi: 10.1016/j.conb.2013.01.010. Epub 2013 Jan 31. Review. PubMed PMID: 23375167; PubMed Central PMCID: PMC3776408.
  • Britt JP, Bonci A. Alcohol and tobacco: how smoking may promote excessive drinking. Neuron. 2013 Aug 7;79(3):406-7. doi: 10.1016/j.neuron.2013.07.018. PubMed PMID: 23931990; PubMed Central PMCID: PMC4130210.
  • Mereu M, Bonci A, Newman AH, Tanda G. The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders. Psychopharmacology (Berl). 2013 Oct;229(3):415-34. doi: 10.1007/s00213-013-3232-4. Epub 2013 Aug 10. Review. PubMed PMID: 23934211; PubMed Central PMCID: PMC3800148.
  • Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct;37(10):1680-7. doi: 10.1111/acer.12153. Epub 2013 Jun 13. PubMed PMID: 23763790; PubMed Central PMCID: PMC3985436.
  • Takahashi YK, Chang CY, Lucantonio F, Haney RZ, Berg BA, Yau HJ, Bonci A, Schoenbaum G. Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning. Neuron. 2013 Oct 16;80(2):507-18. doi: 10.1016/j.neuron.2013.08.008. PubMed PMID: 24139047; PubMed Central PMCID: PMC3806218.
  • Kumar V, Kim K, Joseph C, Kourrich S, Yoo SH, Huang HC, Vitaterna MH, de Villena FP, Churchill G, Bonci A, Takahashi JS. C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science. 2013 Dec 20;342(6165):1508-12. doi: 10.1126/science.1245503. PubMed PMID: 24357318; PubMed Central PMCID: PMC4500108.
  • Ikemoto S, Bonci A. Neurocircuitry of drug reward. Neuropharmacology. 2014 Jan;76 Pt B:329-41. doi: 10.1016/j.neuropharm.2013.04.031. Epub 2013 May 7. Review. PubMed PMID: 23664810; PubMed Central PMCID: PMC3772961.
  • Ilango A, Kesner AJ, Keller KL, Stuber GD, Bonci A, Ikemoto S. Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion. J Neurosci. 2014 Jan 15;34(3):817-22. doi: 10.1523/JNEUROSCI.1703-13.2014. PubMed PMID: 24431440; PubMed Central PMCID: PMC3891961.
  • Haws ME, Jaramillo TC, Espinosa F, Widman AJ, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Stavarache M, Kaplitt M, Bonci A, Powell CM. PTEN knockdown alters dendritic spine/protrusion morphology, not density. J Comp Neurol. 2014 Apr 1;522(5):1171-90. doi: 10.1002/cne.23488. PubMed PMID: 24264880; PubMed Central PMCID: PMC3945606.
  • Marchant NJ, Rabei R, Kaganovsky K, Caprioli D, Bossert JM, Bonci A, Shaham Y. A critical role of lateral hypothalamus in context-induced relapse to alcohol seeking after punishment-imposed abstinence. J Neurosci. 2014 May 28;34(22):7447-57. doi: 10.1523/JNEUROSCI.0256-14.2014. PubMed PMID: 24872550; PubMed Central PMCID: PMC4035512.
  • Tejeda HA, Bonci A. Shedding “UV” light on endogenous opioid dependence. Cell. 2014 Jun 19;157(7):1500-1. doi: 10.1016/j.cell.2014.06.009. PubMed PMID: 24949960.
  • Jayanthi S, McCoy MT, Chen B, Britt JP, Kourrich S, Yau HJ, Ladenheim B, Krasnova IN, Bonci A, Cadet JL. Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms. Biol Psychiatry. 2014 Jul 1;76(1):47-56. doi: 10.1016/j.biopsych.2013.09.034. Epub 2013 Oct 16. PubMed PMID: 24239129; PubMed Central PMCID: PMC3989474.
  • Lee AM, Hoy JL, Bonci A, Wilbrecht L, Stryker MP, Niell CM. Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion. Neuron. 2014 Jul 16;83(2):455-66. doi: 10.1016/j.neuron.2014.06.031. PubMed PMID: 25033185; PubMed Central PMCID: PMC4151326.
  • McDevitt RA, Tiran-Cappello A, Shen H, Balderas I, Britt JP, Marino RA, Chung SL, Richie CT, Harvey BK, Bonci A. Serotonergic versus nonserotonergic dorsal raphe projection neurons: differential participation in reward circuitry. Cell Rep. 2014 Sep 25;8(6):1857-69. doi: 10.1016/j.celrep.2014.08.037. Epub 2014 Sep 18. PubMed PMID: 25242321; PubMed Central PMCID: PMC4181379.
  • Siniscalchi A, Bonci A, Mercuri NB, De Siena A, De Sarro G, Malferrari G, Diana M, Gallelli L. Cocaine dependence and stroke: pathogenesis and management. Curr Neurovasc Res. 2015;12(2):163-72. Review. PubMed PMID: 25742568.
  • Kusumoto-Yoshida I, Liu H, Chen BT, Fontanini A, Bonci A. Central role for the insular cortex in mediating conditioned responses to anticipatory cues. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1190-5. doi: 10.1073/pnas.1416573112. Epub 2015 Jan 12. PubMed PMID: 25583486; PubMed Central PMCID: PMC4313852.
  • Mejias-Aponte CA, Ye C, Bonci A, Kiyatkin EA, Morales M. A subpopulation of neurochemically-identified ventral tegmental area dopamine neurons is excited by intravenous cocaine. J Neurosci. 2015 Feb 4;35(5):1965-78. doi: 10.1523/JNEUROSCI.3422-13.2015. PubMed PMID: 25653355; PubMed Central PMCID: PMC4315830.
  • Kourrich S, Calu DJ, Bonci A. Intrinsic plasticity: an emerging player in addiction. Nat Rev Neurosci. 2015 Mar;16(3):173-84. doi: 10.1038/nrn3877. Review. PubMed PMID: 25697160.
  • Zhang S, Qi J, Li X, Wang HL, Britt JP, Hoffman AF, Bonci A, Lupica CR, Morales M. Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons. Nat Neurosci. 2015 Mar;18(3):386-92. doi: 10.1038/nn.3945. Epub 2015 Feb 9. PubMed PMID: 25664911; PubMed Central PMCID: PMC4340758.
  • Jasinska AJ, Chen BT, Bonci A, Stein EA. Dorsal medial prefrontal cortex (MPFC) circuitry in rodent models of cocaine use: implications for drug addiction therapies. Addict Biol. 2015 Mar;20(2):215-26. doi: 10.1111/adb.12132. Epub 2014 Mar 13. Review. PubMed PMID: 24620898; PubMed Central PMCID: PMC4163139.
  • Wang DV, Yau HJ, Broker CJ, Tsou JH, Bonci A, Ikemoto S. Mesopontine median raphe regulates hippocampal ripple oscillation and memory consolidation. Nat Neurosci. 2015 May;18(5):728-35. doi: 10.1038/nn.3998. Epub 2015 Apr 13. PubMed PMID: 25867120; PubMed Central PMCID: PMC4414896.
  • Pignatelli M, Bonci A. Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective. Neuron. 2015 Jun 3;86(5):1145-57. doi: 10.1016/j.neuron.2015.04.015. Review. PubMed PMID: 26050034.
  • Zhang F, Tsai HC, Airan RD, Stuber GD, Adamantidis AR, de Lecea L, Bonci A, Deisseroth K. Optogenetics in Freely Moving Mammals: Dopamine and Reward. Cold Spring Harb Protoc. 2015 Aug 3;2015(8):715-24. doi: 10.1101/pdb.top086330. PubMed PMID: 26240415.
  • Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW. D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. Neuropsychopharmacology. 2015 Sep;40(10):2357-67. doi: 10.1038/npp.2015.84. Epub 2015 Mar 24. PubMed PMID: 25801502; PubMed Central PMCID: PMC4538350.
  • Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI. Optogenetics: 10 years after ChR2 in neurons–views from the community. Nat Neurosci. 2015 Sep;18(9):1202-12. doi: 10.1038/nn.4106. Review. PubMed PMID: 26308981.
  • Webber ES, Bonci A, Krashes MJ. The elegance of energy balance: Insight from circuit-level manipulations. Synapse. 2015 Sep;69(9):461-74. doi: 10.1002/syn.21837. PubMed PMID: 26126768.
  • Tsai SY, Chuang JY, Tsai MS, Wang XF, Xi ZX, Hung JJ, Chang WC, Bonci A, Su TP. Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6562-70. doi: 10.1073/pnas.1518894112. Epub 2015 Nov 9. PubMed PMID: 26554014; PubMed Central PMCID: PMC4664336.
  • Siniscalchi A, Bonci A, Biagio Mercuri N, Pirritano D, Squillace A, De Sarro G, Gallelli L. The Role of Topiramate in the Management of Cocaine Addiction: a Possible Therapeutic Option. Curr Neuropharmacol. 2015 Nov 26;13(6):815-8. PubMed PMID: 26630959.
  • Kravitz AV, Tomasi D, LeBlanc KH, Baler R, Volkow ND, Bonci A, Ferré S. Cortico-striatal circuits: Novel therapeutic targets for substance use disorders. Brain Res. 2015 Dec 2;1628(Pt A):186-98. doi: 10.1016/j.brainres.2015.03.048. Epub 2015 Apr 9. Review. PubMed PMID: 25863130.
  • Whitaker LR, Carneiro de Oliveira PE, McPherson KB, Fallon RV, Planeta CS, Bonci A, Hope BT. Associative Learning Drives the Formation of Silent Synapses in Neuronal Ensembles of the Nucleus Accumbens. Biol Psychiatry. 2016 Aug 1;80(3):246-56. doi: 10.1016/j.biopsych.2015.08.006. PubMed PMID: 26386479
  • Terraneo A, Leggio L, Saladini M, Ermani M, Bonci A*, Gallimberti L. Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study. Eur Neuropsychopharmacol. 2016 Jan;26(1):37-44. doi: 10.1016/j.euroneuro.2015.11.011. Epub 2015 Dec 4. PubMed PMID: 26655188. *Corresponding author
  • Belin-Rauscent A, Fouyssac M, Bonci A, Belin D. How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction. Biol Psychiatry. 2016 Jan 1;79(1):39-46. doi: 10.1016/j.biopsych.2015.01.004. Epub 2015 Jan 29. Review. PubMed PMID: 25747744.
  • Chang CY, Esber GR, Marrero-Garcia Y, Yau HJ, Bonci A, Schoenbaum G. Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors. Nat Neurosci. 2016 Jan;19(1):111-6. doi: 10.1038/nn.4191. Epub 2015 Dec 7. PubMed PMID: 26642092; PubMed Central PMCID: PMC4696902.
  • Roseberry TK, Lee AM, Lalive AL, Wilbrecht L, Bonci A, Kreitzer AC. Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia. Cell. 2016 Jan 28;164(3):526-37. doi: 10.1016/j.cell.2015.12.037. PubMed PMID: 26824660.
  • Marchant NJ, Campbell EJ, Whitaker LR, Harvey BK, Kaganovsky K, Adhikary S, Hope BT, Heins RC, Prisinzano TE, Vardy E, Bonci A, Bossert JM, Shaham Y. Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence. J Neurosci. 2016 Mar 16;36(11):3281-94. doi: 10.1523/JNEUROSCI.4299-15.2016. PubMed PMID: 26985037.
  • Zhang HY, Gao M, Shen H, Bi GH, Yang HJ, Liu QR, Wu J, Gardner EL, Bonci A, Xi ZX. Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats. Addict Biol. 2016 Feb 1. doi: 10.1111/adb.12367. [Epub ahead of print] PubMed PMID: 26833913.
  • Siniscalchi A, Sztajzel R, Bonci A, Malferrari G, De Sarro G, Gallelli L. Editorial: Cocaine and Cerebral Small Vessel: Is it a Negative Factor for Intravenous Thrombolysis? Curr Vasc Pharmacol. 2016 Feb 4;14(3):304-6. PubMed PMID: 26845684.
  • Yau HJ, Wang DV, Tsou JH, Chuang YF, Chen BT, Deisseroth K, Ikemoto S, Bonci A. Pontomesencephalic Tegmental Afferents to VTA Non-dopamine Neurons Are Necessary for Appetitive Pavlovian Learning. Cell Rep. 2016 Sep 6;16(10):2699-710. doi: 10.1016/j.celrep.2016.08.007. Epub 2016 Aug 25. PubMed PMID: 27568569.
  1. Fredriksson I, Adhikary S, Steensland P, Vendruscolo LF, Bonci A, Shaham Y, Bossert JM. Prior Exposure to Alcohol has no Effect on Cocaine Self-Administration and Relapse in Rats: Evidence from a Rat Model that does not Support the Gateway Hypothesis. Neuropsychopharmacology. 2016 Sep 21. doi: 10.1038/npp.2016.209. PubMed PMID: 27649640 [Epub ahead of print]
  • Creed M, Bonci A, Leggio L. Modulating Morphine Context-Induced Drug Memory With Deep Brain Stimulation: More Research Questions by Lowering Stimulation Frequencies? Biol Psychiatry. 2016 Nov 1;80(9):647-649. doi: 10.1016/j.biopsych.2016.08.022. PubMed PMID: 27697154.
  • Haass-Koffler CL, Henry AT, Melkus G, Simms JA, Naemmuddin M, Nielsen CK, Lasek AW, Magill M, Schwandt ML, Momenan R, Hodgkinson CA, Bartlett SE, Swift RM, Bonci A, Leggio L. Defining the role of corticotropin releasing factor binding protein in alcohol consumption. Transl psychiatry. 2016 Nov 15; 6(11):e953. PubMed PMID: 27845775
  • Xin W, Edwards N, Bonci A. VTA dopamine neuron plasticity – the unusual suspects. Eur J Neurosci. 2016 Dec;44(12):2975-2983 Review. PubMed PMID: 27711998.
  • Tejeda HA, Wu J, Kornspun A, Pignatelli M, Kashtelyan V, Krashes MJ, Lowell BB, Carlezon WA, Bonci A. Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity. Neuron. 2017 Jan 4;93(1):147-163. PubMed PMID: 28056342.
  • Edwards NJ, Tejeda HA, Pignatelli M, Zhang S, McDevitt RA, Wu J, Bass CE, Bettler B, Morales M, Bonci A. Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior. Nat Neurosci. 2017 Jan 23. doi: 10.1038/nn.4482. [Epub ahead of print] PubMed PMID: 28114294.
  • Pignatelli M, Umanah G, Riberio SP, Chen R, Yau HJ, Dawson VL, Dawson TM, Bonci A. Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning. Neuron. 2017 Jan 18;93(2):425-440. PubMed PMID: 28103482.
  • De Biase LM, Schuebel KE, Fusfeld ZH, Jair K, Hawes IA, Cimbro R, Zhang HY, Liu QR, Shen H, Xi ZX, Goldman D, Bonci A. Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia. Neuron. 2017 Jul 19;95(2):341-356.e6. doi: 10.1016/j.neuron.2017.06.020. Epub 2017 Jul 6. PubMed PMID: 28689984.
  • Gomez JL, Bonaventura J, Lesniak W, Mathews WB, Sysa-Shah P, Rodriguez LA, Ellis RJ, Richie CT, Harvey BK, Dannals RF, Pomper MG, Bonci A, Michaelides M. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine. Science. 2017 Aug 4;357(6350):503-507. doi: 10.1126/science.aan2475. PubMed PMID: 28774929.
  • Whitaker LR, Warren BL, Venniro M, Harte TC, McPherson KB, Bossert JM, Shaham Y, Bonci A, Hope BT. Bidirectional modulation of intrinsic excitability in rat prelimbic cortex neuronal ensembles and non-ensembles following operant learning. J Neurosci. 2017 Aug 4. pii: 3761-16. doi: 10.1523/JNEUROSCI.3761-16.2017. Epub 2017 Aug 4. PubMed PMID: 28779019; PubMed Central PMCID: PMC5588469.
  • Diana M, Raij T, Melis M, Nummenmaa A, Leggio L, Bonci A. Rehabilitating the addicted brain with transcranial magnetic stimulation. Nat Rev Neurosci. 2017 Nov;18(11):685-693. doi: 10.1038/nrn.2017.113. Epub 2017 Sep 29. Review. PubMed PMID: 28951609.
  • Umanah GKE, Pignatelli M, Yin X, Chen R, Crawford J, Neifert S, Scarffe L, Behensky AA, Guiberson N, Chang M, Ma E, Kim JW, Castro CC, Mao X, Chen L, Andrabi SA, Pletnikov MV, Pulver AE, Avramopoulos D, Bonci A, Valle D, Dawson TM, Dawson VL. Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel. Sci Transl Med. 2017 Dec 13;9(420). pii: eaah4985. doi: 10.1126/scitranslmed.aah4985. PubMed PMID: 29237760.
  • Pignatelli M, Bonci A. Spiraling Connectivity of NAc-VTA Circuitry. Neuron. 2018 Jan 17;97(2):261-262. doi: 10.1016/j.neuron.2017.12.046. PubMed PMID: 29346748.
  • Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S. Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor. Nat Commun. 2018 Feb 5;9(1):486. doi: 10.1038/s41467-017-02606-w. PubMed PMID: 29402888; PubMed Central PMCID: PMC5799184.
  • Pettorruso M, Spagnolo PA, Leggio L, Janiri L, Di Giannantonio M, Gallimberti L, Bonci A, Martinotti G. Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may improve symptoms of anhedonia in individuals with cocaine use disorder: A pilot study. Brain Stimul. 2018 Jun 5. pii: S1935-861X(18)30165-7. doi: 10.1016/j.brs.2018.06.001. [Epub ahead of print] PubMed PMID: 29885861.
  • Zhang HY, Shen H, Jordan CJ, Liu QR, Gardner EL, Bonci A, Xi ZX. CB2 receptor antibody signal specificity: correlations with the use of partial CB2-knockout mice and anti-rat CB2 receptor antibodies. Acta Pharmacol Sin. 2018 Jul 2. doi: 10.1038/s41401-018-0037-3. [Epub ahead of print] PubMed PMID: 29967455.
  • Xin W, Bonci A. Functional Astrocyte Heterogeneity and Implications for Their Role in Shaping Neurotransmission. Front Cell Neurosci. 2018 May 24;12:141. doi: 10.3389/fncel.2018.00141. eCollection 2018. Review. PubMed PMID: 29896091; PubMed Central PMCID: PMC5987431.
  • Xin W, Schuebel KE, Jair KW, Cimbro R, De Biase LM, Goldman D, Bonci A. Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling. Neuropsychopharmacology. 2018 Jul 13. doi: 10.1038/s41386-018-0151-4. [Epub ahead of print] PubMed PMID: 30054584.
  • Francis TC, Gantz SC, Moussawi K, Bonci A. Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine. Curr Opin Neurobiol. 2018 Sep 17;54:66-72. doi: 10.1016/j.conb.2018.08.013. [Epub ahead of print] Review. PubMed PMID: 30237117.
  • Tejeda HA, Bonci A. Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders. Brain Res. 2018 Sep 19. pii: S0006-8993(18)30488-8. doi: 10.1016/j.brainres.2018.09.023. [Epub ahead of print] Review. PubMed PMID: 30244022.
  • De Biase LM, Bonci A. Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues. Neuroscientist. 2018 Oct 3:1073858418800996. doi: 10.1177/1073858418800996. [Epub ahead of print] PubMed PMID: 30280638.
  • Shen H, Marino RAM, McDevitt RA, Bi GH, Chen K, Madeo G, Lee PT, Liang Y, De Biase LM, Su TP, et al. Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice. Proc Natl Acad Sci U S A. 2018 Nov 15. pii: 201800886. doi: 10.1073/pnas.1800886115. [Epub ahead of print] PubMed PMID: 30442663.
  • Spagnolo PA, Gómez Pérez LJ, Terraneo A, Gallimberti L, Bonci A. Neural Correlates of Cue- and Stress-induced Craving in Gambling Disorders: Implications for Transcranial Magnetic Stimulation Interventions. Eur J Neurosci. 2018 Dec 21. doi: 10.1111/ejn.14313. [Epub ahead of print] PubMed PMID: 30575160.
  • Hu, Y., Salmeron, B.J., Krasnova, I.N., Gu, H., Lu, H., Bonci, A., Cadet, J.L., Stein, E.A. Yang, Y. Compulsive Drug Use is Associated with Imbalance of Orbitofrontal- and Prelimbic- Striatal Circuits in Punishment-Resistant Individuals. PNAS 2018 Dec 4;115(49): E11532-E11541. doi: 10.1073.
  • Jackson, S.N., Barbacci, D.C., Bonci, A.,Woods, A.S., Jackson, S.N., Barbacci, D.C., Bonci, A., An In Vitro Study of Aromatic Stacking of Drug Molecules, Journal Am. Soc. Mass Spectrum, 2019.
  • Xin, W., Mironova, Y.A., Shen, H., Marino, R.A.M., Waisman, A., Lamers, W.H., Bergles, D.E., Bonci. A. Oligodendrocytes support neuronal glutamatergic transmission via expression of glutamine synthetase, Cell Reports 2019. (in press).
  • Francis T.C., Yano H., Demarest T.G., Shen H., Bonci A. (2019) High Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs. Neuron, In Press

Books and Book Chapters

  1. Bonci A, Bernardi G, Calabresi P, Mercuri NB. (1993) Effetti dell’anossia sui neuroni dopaminergici mesencefalici di ratto. Atti XX Riunione LIMPE. Patologia extrapiramidale degenerativa e iatrogena. Varese. 79-89.
  2. Stefani A, Calabresi P, Mercuri NB, Stratta F, Pisani A, Bonci A, Bernardi G. (1994). Basic electrophysiology and possible new therapeutic approaches to movement disorders. In Percheron G (Ed.) Basal Ganglia IV. (pp 229-236). New York, NY: Plenum Press.
  3. Stefani A, De Murtas M, Pisani A, Stratta F, Bonci A, Mercuri NB, Calabresi P. (1995). Electrophysiology of dopamine D1 receptors in the basal ganglia: old facts and new perspectives. Prog. Neuro-Psychopharmacology 19, pp.779-793.
  4. Bonci A, Jones S. (2007). The Mesocortical Dopaminergic System. In Miller B, Cummings J. (Eds.), Human Frontal Lobes, Function and Disorders, 2nd(pp.145-162). New York, NY: Guilford Press.
  5. Hopf W, Bonci A, Malenka R. (2010) Plasticity of forebrain dopamine systems. In Iverson J, Iverson S, Dunnett S, Bjorklund A (Eds.), Dopamine Handbook.(pp. 339-348). New York, NY: Oxford.
  6. Bonci A, Volkow V. (Section Eds.) (2013). Substance Use Disordered. In Charney D, Sklar P, Buxbaum J, Nester E. (Eds.) Neurobiology of Mental Illness 4thedition. New York, NY: Oxford Press.
  7. Kourrich S, Bonci A. (2013). Synaptic and Neural Plasticity. In Charney D, Sklar P, Buxbaum J, Nester E. (Eds.) Neurobiology of Mental Illness 4thedition. (pp. 64-75) New York, NY: Oxford Press.
  8. Michaelides M & Bonci A. (2015) Emerging experimental techniques in neuroscience: Optogenetics. In: Pfaff, DW & Volkow, ND (Eds.), Neuroscience in the 21st Century, 2nd edition. New York: Springer


  1. Phillips K, Bonci A. (2017) Chapter447: Cocaine and Other Commonly Used Drugs.  In: Hauser, S (Ed), Harrison’s Principles of Internal Medicine, 20th edition New York, NY: McGraw-Hill


  1. Chen BT, Bonci A. (2017) Chapter 2: The Mesocortical Dopaminergic System. In Miller B, Cummins J (Eds.) The Human Frontal Lobes Functions and Disorders 3rdEdition. (pp.13-28) New York, NY: Gilford Press.